\tracinglostchars=2

\usepackage{fontspec}
\usepackage[Latin,NumberForms,Punctuation,Symbols]{ucharclasses}

\newfontfamily{\mydefaultfont}{Symbola}
\newfontfamily{\mymainfont}{DejaVu Sans}

\setTransitionsForSymbols{\mydefaultfont}{\mymainfont}
\setTransitionsFor{NumberForms}{\mydefaultfont}{\mymainfont}
\setTransitionTo{Punctuation}{\mymainfont}
\setTransitionTo{Latin}{\mymainfont}